Have you verified the game files on steam after getting rid of the mods? This would help fix any problem that the mods might have caused before removing them. You do seem to have good specs, so I don’t think it’s an aoptmization issue.
Other possible solutions I have found online:
I think could be using the shift on the left instead of the shift on the right.
Using Ctrl + Shift + Windows Key + C to open the cheat menu, works on some computer models.
Increasing page file size sometimes fixes freezing and crashing issues. There’s a quick tutorial here.
If none of this helps, I hope you get a solution soon. Good luck!